On January 27th 2005, Nancy joined forces with Cyndi Lauper and Sandra Bernhard in a fund-raising concert at CROBAR in New York city, to benefit victims of the East Asian Tsunami.

In spring 2005, Nancy was profiled on the popular CBS Sunday Morning television program.

The self-titled CD, NANCY SINATRA, was released in September 2004 on the ATTACK/Sanctuary Records label. It is a series of collaborations with recording artists such as Morrissey, Jon Spencer, Reno, Calexico, Sonic Youth, Pete Yorn, Steve Van Zandt, Jarvis Cocker and Bono. The first live presentation of songs from the new album occurred in a sold out performance by Nancy and her band at the Meltdown Festival in London’s Royal Festival Hall. The first single released was the Morrissey penned “Let Me Kiss You” which charted in the UK. Since it’s release, the album has made the BEST OF lists around the world, including Billboard, Blender, New York Times and Guardian UK.

In late 2005, Audio Bullys built a new song around Nancy’s recording of “Bang, Bang” titled “Shot You Down”, which quickly climbed the charts in the UK, becoming Nancy’s first hit from the dance clubs.

THE ESSENTIAL NANCY SINATRA, a collection of 26 songs covering 5 decades of Nancy's recordings, was released in the UK and Europe, on March 13th 2006, by EMI. It includes the unreleased 1970's track "Machine Gun Kelly", in addition to many of the hits and a few fan favorites.

Nancy recorded the opening and closing themes for noted screen writer and director Todd Stephens' latest project, "Another Gay Movie", a satire of the popular teen coming of age films, which was released 2006 and is now available on DVD. 2008’s “Another Gay Sequel”, contains a remix of the title track and 2 early recordings, written by Nancy herself, “It’s Spring” and “One Way”. The film is available on DVD.

On October 14th, 2006 Nancy was honored with The Heart of a Patriot Award, by the USO of Chicago, “for her years of admiration and support for the Troops and Veterans”.

Nancy received a star on the Hollywood Walk of Fame, May 11th 2006, in recognition of her career achievements and her contributions to society. Nancy has also been honored with stars on the Palm Springs Walk of Stars and the International Walk of Fame Star Blvd., in Rotterdam.

The Viet Nam Veterans of America honored Nancy with their President’s Award for Excellence in the Arts, at their national convention on July 21st, 2007

In May 2007, Nancy launched her weekly 3 hour radio show, “Nancy for Frank” on Sirius/(XM Satellite Radio’s (Channels 75 and 73 respectively), “Siriusly Sinatra”. Each week, Nancy treats listeners to recordings by her dad and other artists singing from the pages of the American Songbook as well as some of her personal favorite songs from all genres. Nancy’s show features rare recordings from the family archives, plus reflections on her life with Frank and her observations about his music.

Currently in production are a Jazz CD project, where Nancy has recorded with players who regularly backed Frank Sinatra on his recordings, a Christmas CD, and compilations featuring more unreleased tracks from Nancy’s vaults. Nancy’s latest project is CHERRY SMILES - THE RARE SINGLES, which had a worldwide digital release September 22, 2009. Released in April 2011, is “Ardent”, Nancy’s contribution to Black Devil Disco Club’s new album titled, “Circus”.